Increased Red Cell Calcium , Decreased Calcium Adenosine
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چکیده
RBCs from four glucose-6-phosphate dehydrogenase (G6PD)-deficient (Mediterranean variant) subjects were studied during fava bean hemolysis. In the density-fractionated RBC calcium level, Ca2 -ATPase activity. reduced glutathione level. and ghost protein pattern were studied. In the bottom fraction, containing most heavily damaged RBCs, calcium level ranged from i43 to 244 smoI/L RBCs (healthy G6PD-deficient controls: 1 7 ± 5 itmol/L RBCs). The Ca2 -ATPase activity ranged from 0.87 to i .84 smol ATP consumed/g Hb/min (healthy G6PD-deficient controls: 2.27 ± 0.4). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of ghosts showed: (1 ) the
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تاریخ انتشار 2005